Biography & Net Worth: Researchers who first predict when bacteria will become resistant to antibiotics

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In a new study led by researchers at UCL and Great Ormond Street Hospital, scientists are the first to search for signs of bacterial “pre-resistance” (a sign that some bacteria are likely to become resistant to antibiotics in the future). Did.

Survey results. published in nature communicationIn the future, doctors will be able to choose the best treatment for bacterial infections.

A team led by Great Ormond Street Hospital (GOSH) and the UCL Great Ormond Street Child Health Institute, working with the Peru Tuberculosis Program and funded by the Wellcome and National Institutes of Health (US), has more than 3,000 There are whole genomes. I did a sequence. A specimen of tuberculosis (TB) that traces the patient to tuberculosis infection for about 20 years.

Mycobacterium tuberculosis (TB) is a bacterial infection that has a major impact on the lungs. It is the second most common cause of infectious death in 2020 after COVID-19, which has killed 1.5 million people. Treatment with the right antibiotics can cure it, but healing takes time and many people at highest risk do not receive proper medical care. Drug-resistant tuberculosis can develop when people have not completed a full course of treatment, or when drugs are not available or of poor quality.

Multi-drug resistant tuberculosis is a huge non-drug burden, and completely drug-resistant strains have been detected in a small number of countries. As the medical system struggles to cope with the pandemic, it has slowed global progress in TB treatment.

This new study identifies for the first time a pre-preventive method to better understand tuberculosis and ultimately improve the treatment of tuberculosis. Before drug resistance mutations occurred. Researchers call this concept “pre-tolerance.” When an organism that causes disease, such as a virus or bacterium, is at high risk of developing drug resistance in the future.

By analyzing thousands of bacterial genomes, this study can be applied to other infectious diseases, drug selection based on the DNA of the specific pathogen that causes disease, and the individual pathogen’s “genome” to drive the development of drug resistance. stops. Pave the way for the “treatment”.

The study is the culmination of 17 years of research in the suburbs of Lima, Peru, and was led by Dr. Louis Grandjean, a GOSH infectious disease consultant and associate professor at the UCL Great Ormond Street Institute of Child Health.

The international team compared tuberculosis samples from 3,135 different specimens to reconstruct a “family tree” of M. tuberculosis, called the phylogeny. The team then used computational analysis to identify the genetic code of the bacterial lineage and then develop drug resistance. By examining the “branches” of the family tree to see which were most likely to develop drug resistance, the team identified key changes associated with the development of resistance.

The authors described how mutations in the tuberculosis genome predicted that certain branches were more likely to become drug-resistant, and validated the results in an independent global TB dataset.

Dr. Grandjean, senior author of the international study, said:

“This is the first example of how we can overtake drugs. Resistance.. This will allow pathogen genomes to be used to select the best treatments in the future.”

PhD student Arturo Torres Ortiz (UCL Great Ormond Street Institute of Child Health), lead author of this paper, said: It is drug-resistant in the future. ,


Largest global study of tuberculosis to date identifies genetic cause of drug resistance


for more information:
Pre-resistant genome signature in Mycobacterium tuberculosis, nature communication (2021). DOI: 10.1038/s41467-021-27616-7

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Source links researchers who predict for the first time that bacteria will become resistant to antibiotics